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            所得成果

            所得成果

                  中康博生物匯聚了生物技術服務及醫藥領域的一批優秀人才,核心管理團隊平均十年以上的行業從業經驗。  在全體員工的努力下,中康博獲得一系列成果和榮譽,“Affymetrix授權服務中心”、“亦莊北京基因芯片優秀實驗室”、“腦膠質瘤研究創新型平臺”、“園區十大優秀企業”等。近些年發表的論文累積影響因子高達300,中康博愿用自己的智慧和汗水幫助生命科學領域客戶快速出成果。加速客戶研究進程,提升客戶研究價值,助力科學研究,推動科技創新。

            中康博基因芯片認證服務商 、營業執照、股權證書:


            中康博計算機軟件著作權:



            中康博部分成果:

             
             
            中康博部分合作項目:
             
            項目名稱 金額(萬)
            造血干細胞調控與再生機制研究 1200
            北京大氣污染對心肺疾病影響的暴露科學、毒理基因組學和環境流行病學綜合研究(APIC-ESTEE) 418.2
            口腔醫學 350
            炎癥微環境在骨骼肌損傷和再生中的作用機制 320
            長鏈非編碼RNA調控肝癌干細胞自我更新的分子機制研究 310
            GALNT1調控膀胱癌干細胞自我更新機制研究 290
            泛素介導的蛋白質降解在心肌肥厚中的作用及機制研究 290
            谷氨酸化修飾的細胞調控機制研究 283
            典型環境污染物與超細顆粒低水平聯合暴露的心血管毒性及機制研究 280
            炎癥微環境在高血壓心臟纖維化發病機制中的研究 280
            炎癥與細胞內外環境調控EMT的機制 270
            趨化因子-受體信號通路調控心力衰竭的發病機制 254
            NURF重塑復合物調控細胞重編程作用及表觀遺傳機制研究 200
            循環系統 (心力衰竭的病理生理機制研究) 200
            心肌纖維化 200
            WASH蛋白復合體調控自噬的功能與結構研究 200
            有效中藥復方功效的指征性物質基礎研究 160
            T淋巴細胞發育與功能 100
            Pcid2調控造血干細胞向淋巴祖細胞譜系建立的分子機制研究 90
            miR-223在腹主動脈瘤發展和干預中的作用及機制研究 80
            α7尼古丁乙酰膽堿受體抗炎通路在高血壓心臟重塑中保護作用及機制 73
            表皮生長因子EREG在牙齒發育中的功能及調控機制研究 70
            神經膠質瘤分子亞型發病機理和診斷方案研究 70
            Foxp1對調節性T細胞和自身免疫病的調控作用 70
            FOXL1抑制胰腺癌腫瘤發生的分子機制研究 70
            肺炎鏈球菌寄居和感染中的唾液酸酶NanC-NanA雙向調節機制研究 70
            牙乳頭不同生物礦化方向關鍵基因的研究 70
            抑癌蛋白H2AX調控肺癌細胞凋亡的轉錄組學分析及其表觀遺傳調控機制研究 70
            去泛素化酶UCHL1激活導致心力衰竭的病理生理機制 63
            PM2.5在肺癌發生過程中的作用及其機制研究 60
            CCP2對3型固有淋巴樣細胞發育分化的調控作用及分子機制研究 60
            Shh信號通路和維甲酸通路在維甲酸致小型豬腭裂中的調控機制研究 60
            microRNA調控心肌細胞增殖能力轉變過程的研究 60
            Tsc1-mTORC1信號對正常和移植造血干細胞的調控作用 57


            中康博合作伙伴





            中康博合作區域




            中康博部分合作文章:

            1. Shuo Wang et al. Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation. Cell. 2017.
            2. Yulin Li et al. Cardiac Fibroblast-Specific Activating Transcription Factor 3 Protects Against Heart Failure by Suppressing MAP2K3-p38 Signaling. Circulation. 2017.
            3. Benyu Liu et al. Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression. Nature immunology. 2017.
            4. Benyu Liu et al. IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development. Nature Communication. 2017.
            5. Di Wu et al. Lkb1 maintains Treg cell lineage identity. Nature Communication. 2017.
             
            Xue-Rui Wang et al. Inhibition of NADPH Oxidase–Dependent Oxidative Stress in the Rostral Ventrolateral Medulla Mediates the Antihypertensive Effects of Acupuncture in Spontaneously Hypertensive Rats. Hypertension. 2017.
             
            6. Comprehensive understanding of PM2.5 on gene and microRNA expression patterns in zebrafish (Danio rerio) model. Science of the Total Environment. 2017.
            7. Genome-wide transcriptional analysis of cardiovascular-related genes and pathways induced by PM2.5 in human myocardial cells. Environ Sci Pollut Res. 2017.
            8. Gene expression profiles and bioinformatics analysis of human umbilical vein endothelial cells exposed to PM2.5. Chemosphere. 2017.
            9. Microarray-based bioinformatics analysis of the combined effects of SiNPs and PbAc on cardiovascular system in zebrafish. Chemosphere. 2017.
            10. Comprehensive gene and microRNA expression profiling on cardiovascular system in zebrafish co-exposured of SiNPs and MeHg. Science of the Total Environment. 2017.
            11. Ling Feng et al. Integrated Analysis of Long Noncoding RNA and mRNA Expression Profile in Advanced Laryngeal Squamous Cell Carcinoma. PLOS One. 2016.
            12. Ling-zhao Meng et al. Aberrant Expression Profile of Long Noncoding RNA in Human Sinonasal Squamous Cell Carcinoma by Microarray Analysis. BioMed Research International. 2016.
            13. Yingying Su et al. Genome-wide DNA methylation profile of developing deciduous tooth germ in miniature pigs. GMC Genomics. 2016
            14. Inflammatory response and blood hypercoagulable state induced by low level co-exposure with silica nanoparticles and benzo[a]pyrene in zebrafish (Danio rerio) embryos. Chemosphere. 2016. IF=3.698.
            15. Pingping Zhu et al. LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells. Nature Communication. 2016.
            16. Genome-wide transcriptional analysis of silica nanoparticle-induced toxicity in zebrafish embryos. Toxicology Research. 2016.
            17. Pingping Zhu et al. ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells. J Clin Invest. 2015.
            18. Yanying Wang et al. The Long Noncoding RNA lncTCF7 Promotes Self-Renewal of Human Liver Cancer Stem Cells through Activation of Wnt Signaling. Cell Stem Cell. 2015 .
            19. Low-dose exposure of silica nanoparticles induces cardiac dysfunction via neutrophil-mediated inflammation and cardiac contraction in zebrafish embryos. Nanotoxicology. 2015.
            20. Xia Wang et al. MicroRNA Let-7i Negatively Regulates Cardiac Inflammation and Fibrosis. Hypertension. 2015.
            21. Yingyu Sun et al. A glioma classification scheme based on coexpression modules of EGFR and PDGFRA. PNAS. 2014 .
            22. Fu Wang et al. Stage-specific differential gene expression profiling and functional network analysis during morphogenesis of diphyodont dentition in miniature pigs, Sus Scrofa. GMC Genomics. 2014.
            23. Rui Dong et al. Comparison of Long Noncoding RNA and mRNA Expression Profiles in Mesenchymal Stem Cells Derived from Human Periodontal Ligament and Bone Marrow. BioMed Research International. 2014.
            24. Dong Ni et al. Downregulation of FOXO3a Promotes Tumor Metastasis and Is Associated with Metastasis-Free Survival of Patients with Clear Cell Renal Cell Carcinoma. Clinical Cancer Research. 2014.
            25. Yong Yang et al. The Noncoding RNA Expression Profile and the Effect of lncRNA AK126698 on Cisplatin Resistance in Non-Small Cell Lung Cancer Cell. PLOS One. 2013.
            26. Chengrong Lu et al. Genome-wide transcriptional analysis of apoptosis-related genes and pathways regulated by H2AX in lung cancer A549 cells. Apoptosis.2013.
            27. YI CUI et al. MicroRNA-181b and microRNA-9 Mediate Arsenic-Induced Angiogenesis via NRP1. CellularPhysiology. 2012.
            28. Xia P et al. DNA sensor cGAS-mediated immune recognition. 2016.
            29. Pengyan Xia et al.  Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection. Nature Inmmunology. 2015
            30. Shuo Wang et al . Autophagy and cell reprogramming. 2014.
            31. Xia P. IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation. Nat Commun. 2015.
            32. Zhu P et al. lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal. Nat Struct Mol Biol. 2016.
            33. Fang JZ et al.  Hepatocyte-Specific Arid1a Deficiency Initiates Mouse Steatohepatitis and Hepatocellular Carcinoma. PLoS One. 2015.
            34. Wang S. Natural Killer-like B Cells Prime Innate Lymphocytes against Microbial Infection. Immunity. 2016.
            35. Wang S. FoxO1-mediated autophagy is required for NK cell development and innate immunity. Nat Commun. 2016.
            36. Zhu P et al. C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling. Nat Commun. 2015.
            37. Li C. The C228T mutation of TERT promoter frequently occurs in bladder cancer stem cells and contributes to tumorigenesis of bladder cancer. Oncotarget. 2015.
            38. Wu S et al. Novel variants in MLL confer to bladder cancer recurrence identified by whole-exome sequencing. Oncotarget. 2016.
            39. Li M et al. T-cell immunoglobulin and ITIM domain (TIGIT) receptor/poliovirus receptor (PVR) ligand engagement suppresses interferon-γ production of natural killer cells via β-arrestin 2-mediated negative signaling. J Biol Chem. 2014.
            40. Ye B et al. Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation. J Exp Med. 2014.
            41. Li C. GALNT1-Mediated Glycosylation and Activation of Sonic Hedgehog Signaling Maintains the Self-Renewal and Tumor-Initiating Capacity of Bladder Cancer Stem Cells. Cancer Res. 2016.
            42. Xia P et al. Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity. Nat Immunol. 2016.
            43. Xia P et al. Insulin-InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages. J Exp Med. 2015.
            44. Yang X et al.  Crystal structures of YfiR from Pseudomonas aeruginosa in two redox states. Biochem Biophys Res Commun. 2015.
            45. Chen J et al. The endoplasmic reticulum adaptor protein ERAdP initiates NK cell activation via the Ubc13-mediated NF-κB pathway. J Immunol. 2015.
            46. Yang X et al. Molecular mechanism for self-protection against the type VI secretion system in Vibrio cholerae.  Acta Crystallogr D Biol Crystallogr. 2014.
            47. Xu M et al. Structural insights into the regulatory mechanism of the Pseudomonas aeruginosa YfiBNR system. Protein Cell. 2016.
            48. Ye B et al. Pcid2 inactivates developmental genes in human and mouse embryonic stem cells to sustain their pluripotency by modulation of EID1 stability. Stem Cells. 2014.
            49. Xia P et al. WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner. J Exp Med. 2014 .
            50. Wang S,et al.  Transient activation of autophagy via Sox2-mediated suppression of mTOR is an important early step in reprogramming to pluripotency. Cell Stem Cell. 2013.
            51. Li C. BCMab1, a monoclonal antibody against aberrantly glycosylated integrin α3β1, has potent antitumor activity of bladder cancer in vivo. Clin Cancer Res. 2014.
            52. Qu Q. et al. Structural characterization of the self-association of the death domain of p75(NTR.). PLoS One. 2013.
            53.  Wang L. Identification of SERPINB1 as a physiological inhibitor of human granzyme H. J Immunol. 2013.
            54. YONG YANG et al. Differences in gene expression profles and carcinogenesis pathways involved in cisplatin resistance of four types of cancer. ONCOLOGY REPORTS.
            55. Wang L. Structural insights into the substrate specificity of human granzyme H: the functional roles of a novel RKR motif. J Immunol. 2017.
            56.  Xia P et al. WASH inhibits autophagy through suppression of Beclin 1 ubiquitination. EMBO J. 2013.
            57.  Xia P et al. Erratum: Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity. Nat Immunol. 2016.
            58. Yang Z al. Single-cell Sequencing Reveals Variants in ARID1A, GPRC5A and MLL2 Driving Self-renewal of Human Bladder Cancer Stem Cells. Eur Urol. 2017 .
            60. Tang H et al. Granzyme H of cytotoxic lymphocytes is required for clearance of the hepatitis B virus through cleavage of the hepatitis B virus X protein. J Immunol. 2012.
            61. Yan X et al.  Mesenchymal stem cells promote hepatocarcinogenesis via lncRNA-MUF interaction with ANXA2 and miR-34a. Cancer Res. 2017.
            62. Zheng X et al. TRIM25 Is Required for the Antiviral Activity of Zinc Finger Antiviral Protein. J Virol. 2017.
            63. Guo Y et al. Valosin-containing protein cleavage by granzyme K accelerates an endoplasmic reticulum stress leading to caspase-independent cytotoxicity of target tumor cells. J Immunol. 2017.
            64. Xia P et al. WASH maintains NKp46+ ILC3 cells by promoting AHR expression. Nat Commun. 2017.
            65. Wang S et al. Natural-Killer-like B Cells Function as a Separate Subset of Innate B Cells. Immunity. 2017.
            66. Hu D et al. Cleavage of survivin by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells. J Biol Chem. 2010.
            67. Wu L et al.  Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme M. J Immunol. 2009.
            68. Hua G et al.  Ignition of p53 bomb sensitizes tumor cells to granzyme K-mediated cytolysis. J Immunol. 2009.
            69. Ye B et al. Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2. Nat Commun. 2017.
            70. Zhang H et al.  Granulysin induces cathepsin B release from lysosomes of target tumor cells to attack mitochondria through processing of bid leading to Necroptosis.  J Immunol. 2009 .
            71.  Shuai Zhang et al. Deficiency of γ&T cells protects against abdominal aortic aneurysms by regulating phosphoinositide 3-kinase/AKT signaling. Journal of Vascular Surgery. 2016.
            72. Xiaoyu Kan et al. Deficiency of IL-12p35 improves cardiac repair after myocardial infarction by promoting angiogenesis. Cardiovascular Research. 2016.
            73. T-T Li et al. Endoplasmic reticulum stress in bone marrow-derived cells prevents acute cardiac inflammation and injury in response to angiotensin II. Cell Death and Disease. 2016.
             
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